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SISU
Vitamin B660 capsules
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Heart Disease
In a study of 742 individuals, 475 with severe coronary artery disease (CAD), and 267 healthy controls, plasma levels of Vitamin B6 were low and markers of inflammation (which is significant in heart disease) were high in individuals with CAD; both were normal in individuals without CAD. In a study of 220 healthy women aged 60 to 91, six-month supplementation with Vitamins B6, B12, and folic acid improved their levels of these nutrients and decreased homocysteine levels. Kidney Disease In a study of 25 dialysis patients, 83 percent were found to have elevated homocysteine levels. For six months, they received B6, B12, and folic acid supplements after dialysis. Eighteen patients finished the study and about three-quarters of them showed normalized homocysteine levels at that time. A similar two-year study of 23 dialysis patients yielded similar results. Pregnancy Elevated homocysteine levels have been linked with a variety of complications in pregnancy, ranging from miscarriage to problems with the placenta (the life-support system linking the fetus to the mother). Low B6 levels (although not necessarily high homocysteine levels) have been linked with fetal heart abnormalities and cleft palate, and may be implicated in other birth defects. These are strong arguments in favour of preventive B6 supplementation, but one more argument is also compelling: Research shows that B6 supplements can substantially and safely reduce nausea and vomiting during pregnancy, helping to make this a happier and healthier time for mother and child. Depression Early studies of B6 and depression occurred in the 1970s among women suffering depression as a result of taking oral contraceptives. This led to studies regarding the effectiveness of B6 in alleviating depression and other symptoms of PMS. Several doubleblind studies supported this. (In some cases in which B6 was not effective, it may have been due to an insufficiency of Vitamin B2 or magnesium, which are necessary to convert B6 to its active form.) Recent studies have gone further by linking low levels of B6 with reduced levels of tryptophan and serotonin, hormones that regulate mood; demonstrating a correlation between B vitamins and depression in women and men; and suggesting a connection between elevated homocysteine and depression in a large study (1000 participants) of men suffering from depression. An easy and safe way to determine whether B6 can be effective in treating depression is simply to try it. Other Important Points about SISU Vitamin B6 • B6 is one of the “powerhouse trio” of B vitamins, which also include B12 and folic acid. Many conditions that respond well to B6 supplementation, such as elevated homocysteine levels, respond even better to the synergy created by taking these three nutrients together. • B2 (riboflavin) and magnesium are essential to converting B6 to its active form. If B6 alone, or B6 with B12 and folic acid, do not bring the desired results, the addition of B2 and magnesium, or simply taking a total B-complex supplement, may help. • Many substances can impair B6 levels, including food dyes, certain drugs (isoniazid, hydralazine, dopamine, and penicillamine), oral contraceptives, alcohol, and excessive protein intake.
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