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SISU
Glucosamine & Chondroitin200 capsules
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Glucosamine
It was once believed that glucosamine had no anti-inflammatory effects, but recent research suggests that it works both by fighting inflammation and inhibiting cartilage degeneration. A meta-analysis (overview) of 20 studies encompassing a total of 2570 patients suggested that daily glucosamine supplements could reduce pain by 28 percent and improve function by 21 percent. Glucosamine proved to be as good as or better than NSAIDs in controlling pain, without risk of adverse effects. It is not clear whether glucosamine can actually rebuild cartilage, but several studies have shown that it can slow progress of the disease over three years. One study showed that it reduced OA-related knee surgeries by 50 percent over five years, even after treatment had stopped. Chondroitin sulfate The usual source of supplemental chondroitin is shark cartilage. However, for more advanced arthritis?and more advanced pain?bovine-source cartilage may be a better choice. Lesser-known but more efficient, bovine cartilage contains 90 percent chondroitin as compared with just 10 percent in shark cartilage. In the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT), 1600 patients with knee OA received a) glucosamine, b) chondroitin, c) glucosamine and chondroitin, d) the arthritis drug celecoxib, or e) placebo daily. After 24 weeks, patients with moderate to severe pain on glucosamine and chondroitin experienced significant reduction in knee pain. Only celecoxib was more effective, but exposed patients to risk of adverse effects. A one-year, placebo-controlled study of 120 patients with knee OA showed that glucosamine and chondroitin could slow progress of the disease. Other Important Points about SISU Glucosamine and Chondroitin It takes up to four weeks for glucosamine and chondroitin to begin taking effect, but the longer they are used, the more pronounced the benefit may be. Individuals with allergies to sulphur drugs or preservatives can use glucosamine sulfate, as it occurs naturally in the human body and does not cause allergic reactions. Research has shown glucosamine sulfate to be as effective as another often-recommended form of glucosamine (hydrochloride).
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