Niacin

Antioxidants, essential fatty acids, and B vitamins, including niacin, are the most commonly used supplements for regulating cholesterol levels. When these changes alone are ineffective, niacin supplements may be combined with statin or fibrate drugs. While these drugs have proven effective in lowering LDL ("bad") cholesterol, niacin is more effective in raising HDL ("good") cholesterol, which is increasingly recognized as an important measure of heart health.

In some people, niacin causes a harmless but annoying flushing reaction. Drug companies produce prolonged-release niacin, which counteracts this effect in most people. However, some research suggests that prolonged-release niacin can cause liver damage. Moreover, it doesn't counteract the flushing effect in all people. Some studies suggest that the form of niacin used in Cool B3, inositol hexanicotinate, may be equally effective, without adverse effects.

Vitamin B12 and folic acid
Cool B3 also contains Vitamin B12 and folic acid. These are included because niacin has been found to increase levels of homocysteine, an amino acid metabolite that can have many damaging effects at elevated levels. Vitamin B12 and folic acid have been found to reduce homocysteine levels, balancing out the impact of niacin.

Regulating homocysteine levels is important to many aspects of your health as you get older. Elevated homocysteine has been linked with heart disease, neurological decline (such as Alzheimer's disease), and osteoporosis. As the years pass, you are at increasing risk of developing these debilitating conditions because your body will tend to accrue deficiencies of B vitamins with age. Cool B3 therefore supports many aspects of health.

Other Important Points about SISU Cool B3:
Niacin has been shown to be an effective treatment for Raynaud's Syndrome, a condition in which spasms in the digital arteries cause the hands and fingers to become numb or painful when cold.

Studies have also shown niacin effective in the treatment of intermittent claudication, a condition in which spasms in the leg arteries cause walking to be painful, and limit the individual's ability to walk more than short distances.

Each gelatin capsule contains:

Niacin (from non-flushing inositol hexanicotinate)...500 mg
Vitamin B12 (cyanocobalamin)...300 mcg
Folic acid...0.3 mg

excipients: magnesium stearate (vegetable), microscrystalline cellulose.