Common alpha lipoic acid supplements are a 50/50 mixture of the natural R lipoic acid, and the synthetic S lipoic acid. These mixtures are called “racemates.” In some cases, S (–) lipoic acid is simply less effective than R (+) lipoic acid. But in other cases, the S form actually acts in opposition to the activity of R lipoic acid. Only the R(+) enantiomer exists in nature and is an essential cofactor of four mitochondrial enzyme complexes and is th eonly form our bodies can synthesize.

Alpha lipoic acid also plays an important role in the synergism of antioxidants, what some doctors prefer to call the body’s “antioxidant network”. It directly recycles and extends the metabolic life spans of vitamin C, glutathione, and coenzyme Q10, and it indirectly renews vitamin E.

In Germany, alpha lipoic acid is an approved medical treatment for peripheral neuropathy, a common complication of diabetes. It speeds the removal of glucose from the bloodstream, at least partly by enhancing insulin function, and it reduces insulin resistance, an underpinning of many cases of coronary heart disease and obesity. The therapeutic dose for lipoic acid is 600 mg daily (the richest food source of alpha lipoic acid is red meat.)

From a therapeutic viewpoint, few natural antioxidants are ideal. An ideal therapeutic antioxidant should fulfill several criteria. These include absorption from the diet, conversion in cells and tissues into usable form, a variety of antioxidant actions (including interactions with other antioxidants) in both membrane and aqueous phases, and low toxicity. Alpha lipoic acid is unique among natural antioxidants in its ability to be a highly effective therapeutic agent in a number of conditions in which oxidative damage has been implicated.


Suggested Use: As a dietary supplement, take 1-2 capsule daily with a meal, or as directed by your health care practitioner.

Each vegetable capsule contains: